Douglaston was colonized in the 17th century by the British and Dutch. The original inhabitants who lived there, the Matinecock people, are part of the larger Algonquin nation. While the Matinecock people are said to have sold land to the Dutch, there was also documented violence against them prior to this, as well as a smallpox epidemic that devastated the community years later in 1652. Others were forcibly removed from the land by Thomas Hicks. Members of the Matinecock tribe remain in Queens today.

Douglaston is located on the North Shore of Long Island, bordered to the east by Little Neck, and to the west by Bayside. It represents one of the least traditionally urban communities in New York City, with many areas having a distinctly upscale suburban feel, similar to that of Nassau County towns located nearby.

George Douglas purchased land in the area in 1835, and his son William Douglas later donated a Long Island Rail Road Stop.